Publications – The Lüders Lab

2023

Gallisà-Suñé N, Sànchez-Fernàndez-de-Landa P, Zimmermann F, Serna M, Regué L, Paz J, Llorca O, Lüders J and Roig J. BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M. (2023) Nat Commun. 14, 2434 Pubmed Nat Commun PMC Article

Lüders J. Microtubule cytoskeleton: The centrosome gains a membrane. (2023) Curr Biol. 33, R180-R182 Pubmed Curr Biol

Ali A, Vineethakumari C, Lacasa C and Lüders J. Microtubule nucleation and γTuRC centrosome localization in interphase cells require ch-TOG. (2023) Nat Commun. 14, 289 Pubmed Nat Commun PMC Article

2022

Shankar S, Hsu ZT, Ezquerra A, Li CC, Huang TL, Coyaud E, Viais R, Grauffel C, Raught B, Lim C, Lüders J, Tsai SY and Hsia KC. Α γ-tubulin complex-dependent pathway suppresses ciliogenesis by promoting cilia disassembly. (2022) Cell Rep. 41, 111642 Pubmed Cell Rep

Dutto I, Gerhards J, Herrera A, Souckova O, Škopová V, Smak JA, Junza A, Yanes O, Boeckx C, Burkhalter MD, Zikánová M, Pons S, Philipp M, Lüders J and Stracker TH. Pathway-specific effects of ADSL deficiency on neurodevelopment. (2022) Elife. 11, Pubmed Elife PMC Article

Vineethakumari C and Lüders J. Microtubule Anchoring: Attaching Dynamic Polymers to Cellular Structures. (2022) Front Cell Dev Biol. 10, 867870 Pubmed Front Cell Dev Biol PMC Article

2021

Lovera M and Lüders J. The ciliary impact of nonciliary gene mutations. (2021) Trends Cell Biol. 31, 876-887 Pubmed Trends Cell Biol

Schweizer N, Haren L, Dutto I, Viais R, Lacasa C, Merdes A and Lüders J. Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold. (2021) Nat Commun. 12, 6042 Pubmed Nat Commun PMC Article

Viais R, Fariña-Mosquera M, Villamor-Payà M, Watanabe S, Palenzuela L, Lacasa C and Lüders J. Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development. (2021) Elife. 10, Pubmed Elife PMC Article

Schweizer N and Lüders J. From tip to toe - dressing centrioles in γTuRC. (2021) J Cell Sci. 134, Pubmed J Cell Sci

2020

Lüders J. Nucleating microtubules in neurons: Challenges and solutions. (2021) Dev Neurobiol. 81, 273-283 Pubmed Dev Neurobiol

Zimmermann F, Serna M, Ezquerra A, Fernandez-Leiro R, Llorca O and Luders J. Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase. (2020) Sci Adv. 6, Pubmed Sci Adv

Parcerisas A, Pujadas L, Ortega-Gascó A, Perelló-Amorós B, Viais R, Hino K, Figueiro-Silva J, La Torre A, Trullás R, Simó S, Lüders J and Soriano E. NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3. (2020) Cereb Cortex. 30, 3781-3799 Pubmed Cereb Cortex PMC Article

Ezquerra A, Viais R and Lüders J. Assaying Microtubule Nucleation. (2020) Methods Mol Biol. 2101, 163-178 Pubmed Methods Mol Biol

2018

Freixo F, Martinez Delgado P, Manso Y, Sánchez-Huertas C, Lacasa C, Soriano E, Roig J and Lüders J. NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization. (2018) Nat Commun. 9, 2330 Pubmed Nat Commun PMC Article

Lüders J. XMAP215 joins microtubule nucleation team. (2018) Nat Cell Biol. 20, 508-510 Pubmed Nat Cell Biol

2017

Paz J and Lüders J. Microtubule-Organizing Centers: Towards a Minimal Parts List. (2018) Trends Cell Biol. 28, 176-187 Pubmed Trends Cell Biol

2016

Cota RR, Teixidó-Travesa N, Ezquerra A, Eibes S, Lacasa C, Roig J and Lüders J. MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation. (2017) J Cell Sci. 130, 406-419 Pubmed J Cell Sci

Sánchez-Huertas C, Freixo F, Viais R, Lacasa C, Soriano E and Lüders J. Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity. (2016) Nat Commun. 7, 12187 Pubmed Nat Commun PMC Article

Lecland N and Lüders J. Imaging and Quantifying the Dynamics of γ-Tubulin at Microtubule Minus Ends in Mitotic Spindles. (2016) Methods Mol Biol. 1413, 63-75 Pubmed Methods Mol Biol

2015

Marjanović M, Sánchez-Huertas C, Terré B, Gómez R, Scheel JF, Pacheco S, Knobel PA, Martínez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Lüders J and Stracker TH. CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination. (2015) Nat Commun. 6, 7676 Pubmed Nat Commun PMC Article

Sánchez-Huertas C and Lüders J. The augmin connection in the geometry of microtubule networks. (2015) Curr Biol. 25, R294-9 Pubmed Curr Biol

2014

Lecland N and Lüders J. The dynamics of microtubule minus ends in the human mitotic spindle. (2014) Nat Cell Biol. 16, 770-8 Pubmed Nat Cell Biol

2013

Comartin D, Gupta GD, Fussner E, Coyaud É, Hasegan M, Archinti M, Cheung SW, Pinchev D, Lawo S, Raught B, Bazett-Jones DP, Lüders J and Pelletier L. CEP120 and SPICE1 cooperate with CPAP in centriole elongation. (2013) Curr Biol. 23, 1360-6 Pubmed Curr Biol

Brown NJ, Marjanović M, Lüders J, Stracker TH and Costanzo V. Cep63 and cep152 cooperate to ensure centriole duplication. (2013) PLoS One. 8, e69986 Pubmed PLoS One PMC Article

2012

Lüders J. The amorphous pericentriolar cloud takes shape. (2012) Nat Cell Biol. 14, 1126-8 Pubmed Nat Cell Biol

Teixidó-Travesa N, Roig J and Lüders J. The where, when and how of microtubule nucleation - one ring to rule them all. (2012) J Cell Sci. 125, 4445-56 Pubmed J Cell Sci

Estruch SB, Buzón V, Carbó LR, Schorova L, Lüders J and Estébanez-Perpiñá E. The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function. (2012) PLoS One. 7, e37963 Pubmed PLoS One PMC Article

2010

Teixidó-Travesa N, Villén J, Lacasa C, Bertran MT, Archinti M, Gygi SP, Caelles C, Roig J and Lüders J. The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8. (2010) Mol Biol Cell. 21, 3963-72 Pubmed Mol Biol Cell PMC Article

Archinti M, Lacasa C, Teixidó-Travesa N and Lüders J. SPICE--a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. (2010) J Cell Sci. 123, 3039-46 Pubmed J Cell Sci

2009

Haren L, Stearns T and Lüders J. Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. (2009) PLoS One. 4, e5976 Pubmed PLoS One PMC Article

2007 and earlier

Lüders J and Stearns T. Microtubule-organizing centres: a re-evaluation. (2007) Nat Rev Mol Cell Biol. 8, 161-7 Pubmed Nat Rev Mol Cell Biol

Lüders J, Patel UK and Stearns T. GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation. (2006) Nat Cell Biol. 8, 137-47 Pubmed Nat Cell Biol

Lüders J, Pyrowolakis G and Jentsch S. The ubiquitin-like protein HUB1 forms SDS-resistant complexes with cellular proteins in the absence of ATP. (2003) EMBO Rep. 4, 1169-74 Pubmed EMBO Rep PMC Article

Lüders J, Demand J, Papp O and Höhfeld J. Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chaperone function. (2000) J Biol Chem. 275, 14817-23 Pubmed J Biol Chem

Lüders J, Demand J and Höhfeld J. The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome. (2000) J Biol Chem. 275, 4613-7 Pubmed J Biol Chem

Möller G, Lüders J, Markus M, Husen B, Van Veldhoven PP and Adamski J. Peroxisome targeting of porcine 17beta-hydroxysteroid dehydrogenase type IV/D-specific multifunctional protein 2 is mediated by its C-terminal tripeptide AKI. (1999) J Cell Biochem. 73, 70-8 Pubmed J Cell Biochem

Lüders J, Demand J, Schönfelder S, Frien M, Zimmermann R and Höhfeld J. Cofactor-induced modulation of the functional specificity of the molecular chaperone Hsc70. (1998) Biol Chem. 379, 1217-26 Pubmed Biol Chem

Demand J, Lüders J and Höhfeld J. The carboxy-terminal domain of Hsc70 provides binding sites for a distinct set of chaperone cofactors. (1998) Mol Cell Biol. 18, 2023-8 Pubmed Mol Cell Biol PMC Article