Publications – The Lüders Lab

2021

Schweizer, N, Haren, L, Dutto, I, Viais, R, Lacasa, C, Merdes, A et al.. Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold. Nat Commun. 2021;12 (1):6042. doi: 10.1038/s41467-021-26252-5. PubMed PMID:34654813 PubMed Central PMC8519919.
Viais, R, Fariña-Mosquera, M, Villamor-Payà, M, Watanabe, S, Palenzuela, L, Lacasa, C et al.. Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development. Elife. 2021;10 :. doi: 10.7554/eLife.67989. PubMed PMID:34427181 PubMed Central PMC8456695.
Schweizer, N, Lüders, J. From tip to toe - dressing centrioles in γTuRC. J Cell Sci. 2021;134 (14):. doi: 10.1242/jcs.258397. PubMed PMID:34283237 .
Lovera, M, Lüders, J. The ciliary impact of nonciliary gene mutations. Trends Cell Biol. 2021;31 (11):876-887. doi: 10.1016/j.tcb.2021.06.001. PubMed PMID:34183231 .
Lüders, J. Nucleating microtubules in neurons: Challenges and solutions. Dev Neurobiol. 2021;81 (3):273-283. doi: 10.1002/dneu.22751. PubMed PMID:32324945 .

2020

Zimmermann, F, Serna, M, Ezquerra, A, Fernandez-Leiro, R, Llorca, O, Luders, J et al.. Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase. Sci Adv. 2020;6 (51):. doi: 10.1126/sciadv.abe0894. PubMed PMID:33355144 .
Lüders, J. Nucleating microtubules in neurons: Challenges and solutions. Dev Neurobiol. 2021;81 (3):273-283. doi: 10.1002/dneu.22751. PubMed PMID:32324945 .
Parcerisas, A, Pujadas, L, Ortega-Gascó, A, Perelló-Amorós, B, Viais, R, Hino, K et al.. NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3. Cereb Cortex. 2020;30 (6):3781-3799. doi: 10.1093/cercor/bhz342. PubMed PMID:32043120 PubMed Central PMC7233011.
Ezquerra, A, Viais, R, Lüders, J. Assaying Microtubule Nucleation. Methods Mol Biol. 2020;2101 :163-178. doi: 10.1007/978-1-0716-0219-5_11. PubMed PMID:31879904 .

2018

Freixo, F, Martinez Delgado, P, Manso, Y, Sánchez-Huertas, C, Lacasa, C, Soriano, E et al.. NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization. Nat Commun. 2018;9 (1):2330. doi: 10.1038/s41467-018-04706-7. PubMed PMID:29899413 PubMed Central PMC5997995.
Lüders, J. XMAP215 joins microtubule nucleation team. Nat Cell Biol. 2018;20 (5):508-510. doi: 10.1038/s41556-018-0100-9. PubMed PMID:29695790 .
Paz, J, Lüders, J. Microtubule-Organizing Centers: Towards a Minimal Parts List. Trends Cell Biol. 2018;28 (3):176-187. doi: 10.1016/j.tcb.2017.10.005. PubMed PMID:29173799 .

2017

Cota, RR, Teixidó-Travesa, N, Ezquerra, A, Eibes, S, Lacasa, C, Roig, J et al.. MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation. J Cell Sci. 2017;130 (2):406-419. doi: 10.1242/jcs.195321. PubMed PMID:27852835 .

2016

Sánchez-Huertas, C, Freixo, F, Viais, R, Lacasa, C, Soriano, E, Lüders, J et al.. Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity. Nat Commun. 2016;7 :12187. doi: 10.1038/ncomms12187. PubMed PMID:27405868 PubMed Central PMC4947180.
Lecland, N, Lüders, J. Imaging and Quantifying the Dynamics of γ-Tubulin at Microtubule Minus Ends in Mitotic Spindles. Methods Mol Biol. 2016;1413 :63-75. doi: 10.1007/978-1-4939-3542-0_5. PubMed PMID:27193843 .

2015

Marjanović, M, Sánchez-Huertas, C, Terré, B, Gómez, R, Scheel, JF, Pacheco, S et al.. CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination. Nat Commun. 2015;6 :7676. doi: 10.1038/ncomms8676. PubMed PMID:26158450 PubMed Central PMC4499871.
Sánchez-Huertas, C, Lüders, J. The augmin connection in the geometry of microtubule networks. Curr Biol. 2015;25 (7):R294-9. doi: 10.1016/j.cub.2015.02.006. PubMed PMID:25829017 .

2014

Lecland, N, Lüders, J. The dynamics of microtubule minus ends in the human mitotic spindle. Nat Cell Biol. 2014;16 (8):770-8. doi: 10.1038/ncb2996. PubMed PMID:24976384 .

2013

Brown, NJ, Marjanović, M, Lüders, J, Stracker, TH, Costanzo, V. Cep63 and cep152 cooperate to ensure centriole duplication. PLoS One. 2013;8 (7):e69986. doi: 10.1371/journal.pone.0069986. PubMed PMID:23936128 PubMed Central PMC3728344.
Comartin, D, Gupta, GD, Fussner, E, Coyaud, É, Hasegan, M, Archinti, M et al.. CEP120 and SPICE1 cooperate with CPAP in centriole elongation. Curr Biol. 2013;23 (14):1360-6. doi: 10.1016/j.cub.2013.06.002. PubMed PMID:23810536 .

2012

Teixidó-Travesa, N, Roig, J, Lüders, J. The where, when and how of microtubule nucleation - one ring to rule them all. J Cell Sci. 2012;125 (Pt 19):4445-56. doi: 10.1242/jcs.106971. PubMed PMID:23132930 .
Lüders, J. The amorphous pericentriolar cloud takes shape. Nat Cell Biol. 2012;14 (11):1126-8. doi: 10.1038/ncb2617. PubMed PMID:23131920 .
Estruch, SB, Buzón, V, Carbó, LR, Schorova, L, Lüders, J, Estébanez-Perpiñá, E et al.. The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function. PLoS One. 2012;7 (6):e37963. doi: 10.1371/journal.pone.0037963. PubMed PMID:22675500 PubMed Central PMC3366998.

2010

Teixidó-Travesa, N, Villén, J, Lacasa, C, Bertran, MT, Archinti, M, Gygi, SP et al.. The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8. Mol Biol Cell. 2010;21 (22):3963-72. doi: 10.1091/mbc.E10-05-0408. PubMed PMID:20861304 PubMed Central PMC2982109.
Archinti, M, Lacasa, C, Teixidó-Travesa, N, Lüders, J. SPICE--a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. J Cell Sci. 2010;123 (Pt 18):3039-46. doi: 10.1242/jcs.069963. PubMed PMID:20736305 .

2009

Haren, L, Stearns, T, Lüders, J. Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. PLoS One. 2009;4 (6):e5976. doi: 10.1371/journal.pone.0005976. PubMed PMID:19543530 PubMed Central PMC2695007.

2007 and earlier

Lüders, J, Stearns, T. Microtubule-organizing centres: a re-evaluation. Nat Rev Mol Cell Biol. 2007;8 (2):161-7. doi: 10.1038/nrm2100. PubMed PMID:17245416 .
Lüders, J, Patel, UK, Stearns, T. GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation. Nat Cell Biol. 2006;8 (2):137-47. doi: 10.1038/ncb1349. PubMed PMID:16378099 .
Lüders, J, Pyrowolakis, G, Jentsch, S. The ubiquitin-like protein HUB1 forms SDS-resistant complexes with cellular proteins in the absence of ATP. EMBO Rep. 2003;4 (12):1169-74. doi: 10.1038/sj.embor.7400025. PubMed PMID:14608371 PubMed Central PMC1326417.
Lüders, J, Demand, J, Papp, O, Höhfeld, J. Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chaperone function. J Biol Chem. 2000;275 (20):14817-23. doi: 10.1074/jbc.275.20.14817. PubMed PMID:10809723 .
Lüders, J, Demand, J, Höhfeld, J. The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome. J Biol Chem. 2000;275 (7):4613-7. doi: 10.1074/jbc.275.7.4613. PubMed PMID:10671488 .
Möller, G, Lüders, J, Markus, M, Husen, B, Van Veldhoven, PP, Adamski, J et al.. Peroxisome targeting of porcine 17beta-hydroxysteroid dehydrogenase type IV/D-specific multifunctional protein 2 is mediated by its C-terminal tripeptide AKI. J Cell Biochem. 1999;73 (1):70-8. doi: 10.1002/(sici)1097-4644(19990401)73:1<70::aid-jcb8>3.0.co;2-k. PubMed PMID:10088725 .
Lüders, J, Demand, J, Schönfelder, S, Frien, M, Zimmermann, R, Höhfeld, J et al.. Cofactor-induced modulation of the functional specificity of the molecular chaperone Hsc70. Biol Chem. 1998;379 (10):1217-26. doi: 10.1515/bchm.1998.379.10.1217. PubMed PMID:9820582 .
Demand, J, Lüders, J, Höhfeld, J. The carboxy-terminal domain of Hsc70 provides binding sites for a distinct set of chaperone cofactors. Mol Cell Biol. 1998;18 (4):2023-8. doi: 10.1128/MCB.18.4.2023. PubMed PMID:9528774 PubMed Central PMC121432.